H-151, a Selective STING Inhibitor, Has Potential as a Treatment for Neovascular Age-Related Macular Degeneration

• Published in: Investigative Ophthalmology & Visual Science Vol. 65; no. 8; p. 16
• Main Authors: Tanaka, Miruto, Yasuda, Hiroto, Nakamura, Shinsuke, Shimazawa, Masamitsu
• Format: Journal Article
• Language: English
• Published: United States Association for Research in Vision and Ophthalmology (ARVO) 09.07.2024; The Association for Research in Vision and Ophthalmology
• Subjects: Animals; Blotting, Western; Choroid - metabolism; Choroid - pathology; Choroidal Neovascularization - drug therapy; Choroidal Neovascularization - metabolism; Disease Models, Animal; Fluorescein Angiography; Intravitreal Injections; Macular Degeneration - drug therapy; Macular Degeneration - metabolism; Male; Membrane Proteins - antagonists & inhibitors; Membrane Proteins - metabolism; Mice; Mice, Inbred C57BL; Nucleotidyltransferases - antagonists & inhibitors; Nucleotidyltransferases - metabolism; Retina

The cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS) stimulator of interferon gene (STING) pathway is a crucial cascade in the inflammatory response initiated by the recognition of cytosolic double-stranded DNA (dsDNA). The aim of this study was to evaluate the effect of STING...