A Dual Coverage Monitoring of the Bile Acids Profile in the Liver–Gut Axis throughout the Whole Inflammation-Cancer Transformation Progressive: Reveal Hepatocellular Carcinoma Pathogenesis

• Published in: International journal of molecular sciences Vol. 24; no. 5; p. 4258
• Main Authors: Xing, Luwen, Zhang, Yiwen, Li, Saiyu, Tong, Minghui, Bi, Kaishun, Zhang, Qian, Li, Qing
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 21.02.2023; MDPI
• Subjects: Acids; Amino acids; Analysis; Animals; Bile Acids and Salts - metabolism; Bile ducts; Biomarkers; Carcinoma, Hepatocellular - metabolism; Deoxycholic acid; Development and progression; Discriminant analysis; Hepatitis B; Hepatoma; Homeostasis; Hyperplasia; Inflammation; Inflammation - metabolism; Liver - metabolism; Liver cancer; Liver cirrhosis; Liver Neoplasms - metabolism; Metabolism; Metabolites; Pathogenesis; Plasma; Rats; Trends; China; liver–gut axis; BAAT; bile acids; inflammation-cancer transformation process; hepatocellular carcinoma; enterohepatic circulation

Hepatocellular carcinoma (HCC) is the terminal phase of multiple chronic liver diseases, and evidence supports chronic uncontrollable inflammation being one of the potential mechanisms leading to HCC formation. The dysregulation of bile acid homeostasis in the enterohepatic circulation has become a...