Sigmoid Th17 populations, the HIV latent reservoir, and microbial translocation in men on long-term antiretroviral therapy

• Published in: AIDS (London) Vol. 25; no. 6; pp. 741 - 749
• Main Authors: CHEGE, Duncan, SHETH, Prameet M, KAUL, Rupert, KAIN, Taylor, KIM, Connie J, KOVACS, Colin, LOUTFY, Mona, HALPENNY, Roberta, KANDEL, Gabor, CHUN, Tae-Wook, OSTROWSKI, Mario
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 27.03.2011
• Subjects: Adult; AIDS/HIV; Animals; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiviral agents; Bacterial Translocation - immunology; Biological and medical sciences; CD4-Positive T-Lymphocytes - immunology; Cercopithecus aethiops; Colon, Sigmoid - immunology; HIV Infections - drug therapy; HIV Infections - immunology; HIV Infections - pathology; HIV-1 - physiology; Human immunodeficiency virus; Human viral diseases; Humans; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunopathology; Infectious diseases; Intestinal Mucosa - immunology; Intestinal Mucosa - pathology; Intestinal Mucosa - virology; Male; Medical sciences; Middle Aged; Pharmacology. Drug treatments; Simian Acquired Immunodeficiency Syndrome - immunology; Simian Acquired Immunodeficiency Syndrome - pathology; Simian Immunodeficiency Virus - immunology; Simian Immunodeficiency Virus - pathogenicity; Th17 Cells - immunology; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Human; Immunopathology; Antiretroviral agent; antiretroviral therapy; Retroviridae; Male; Reservoir; AIDS; Asymptomatic; Immune deficiency; Lentivirus; Long term; Infection; Virus; microbial translocation; Chemotherapy; Treatment; provirus; Viral disease; sigmoid colon; Antiviral; Human immunodeficiency virus; Th17 cells

Th17 cells play an important role in mucosal defence and repair and are highly susceptible to infection by HIV. Antiretroviral therapy (ART) suppresses HIV viremia and can restore CD4(+) numbers in the blood and gastrointestinal mucosa, but the resolution of systemic inflammation and gut microbial t...