The Presence of Periodontitis Exacerbates Non-Alcoholic Fatty Liver Disease via Sphingolipid Metabolism-Associated Insulin Resistance and Hepatic Inflammation in Mice with Metabolic Syndrome

• Published in: International journal of molecular sciences Vol. 24; no. 9; p. 8322
• Main Authors: Lu, Zhongyang, Li, Yanchun, Chowdhury, Nityananda, Yu, Hong, Syn, Wing-Kin, Lopes-Virella, Maria, Yilmaz, Özlem, Huang, Yan
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 05.05.2023; MDPI
• Subjects: Alzheimer's disease; Analysis; Animals; Ceramides - metabolism; Diet, High-Fat - adverse effects; Fatty acids; Fatty liver; Gum disease; Imipramine; Imipramine - pharmacology; Inflammation; Inflammation - metabolism; Insulin Resistance; Lipopolysaccharides - pharmacology; Liver - metabolism; Liver diseases; Medical research; Medicine, Experimental; Metabolic syndrome; Metabolic Syndrome - complications; Metabolic Syndrome - metabolism; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease - complications; Non-alcoholic Fatty Liver Disease - metabolism; Nutrition research; Palmitic Acid - pharmacology; Pathogens; Periodontitis; Periodontitis - complications; Periodontitis - metabolism; Physiological aspects; Sphingolipids - metabolism; Triglycerides; Type 2 diabetes; metabolic syndrome; non-alcoholic fatty liver disease; inflammation; acid sphingomyelinase; imipramine; periodontitis

Clinical studies have shown that periodontitis is associated with non-alcoholic fatty liver disease (NAFLD). However, it remains unclear if periodontitis contributes to the progression of NAFLD. In this study, we generated a mouse model with high-fat diet (HFD)-induced metabolic syndrome (MetS) and...