Heat shock-mediated cell cycle blockage and G1 cyclin expression in the yeast Saccharomyces cerevisiae

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Published inMolecular and Cellular Biology Vol. 13; no. 2; pp. 1034 - 1041
Main Authors ROWLEY, A, JOHNSTON, G. C, BUTLER, B, WERNER-WASHBURNE, M, SINGER, R. A
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.02.1993
Subjects
Biological and medical sciences
Cell Cycle - genetics
Cell physiology
Cyclic AMP - metabolism
Cyclins - genetics
Cyclins - metabolism
Effects of physical and chemical agents
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation, Fungal
Hot Temperature
Molecular and cellular biology
Mutation
Protein Kinases - metabolism
Saccharomyces cerevisiae - genetics
Transcription, Genetic
Fungi
Yeast
Thermal shock
Cell cycle
Ascomycetes
Inhibition
Gene expression
Saccharomyces cerevisiae
Nuclear protein
Thallophyta
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Abstract Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue MCB About MCB Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy MCB RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0270-7306 Online ISSN: 1098-5549 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to MCB .asm.org, visit: MCB       
AbstractList For cells of the yeast Saccharomyces cerevisiae, heat shock causes a transient inhibition of the cell cycle-regulatory step START. We have determined that this heat-induced START inhibition is accompanied by decreased CLN1 and CLN2 transcript abundance and by possible posttranscriptional changes to CLN3 (WHI1/DAF1) cyclin activity. Persistent CLN2 expression from a heterologous promoter or the CLN2-1 or CLN3-1 alleles that are thought to encode cyclin proteins with increased stability eliminated heat-induced START inhibition but did not affect other aspects of the heat shock response. Heat-induced START inhibition was shown to be independent of functions that regulate cyclin activity under other conditions and of transcriptional regulation of SWI4, an activator of cyclin transcription. Cells lacking Bcy1 function and thus without cyclic AMP control of A kinase activity were inhibited for START by heat shock as long as A kinase activity was attenuated by mutation. We suggest that heat shock mediates START blockage through effects on the G1 cyclins.
Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue MCB About MCB Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy MCB RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0270-7306 Online ISSN: 1098-5549 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to MCB .asm.org, visit: MCB       
Author A Rowley
G C Johnston
R A Singer
B Butler
M Werner-Washburne
AuthorAffiliation Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
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Issue 2
Keywords Fungi
Yeast
Thermal shock
Cell cycle
Ascomycetes
Inhibition
Gene expression
Saccharomyces cerevisiae
Nuclear protein
Thallophyta
Language English
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Snippet Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley...
For cells of the yeast Saccharomyces cerevisiae, heat shock causes a transient inhibition of the cell cycle-regulatory step START. We have determined that this...
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StartPage 1034
SubjectTerms Biological and medical sciences
Cell Cycle - genetics
Cell physiology
Cyclic AMP - metabolism
Cyclins - genetics
Cyclins - metabolism
Effects of physical and chemical agents
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation, Fungal
Hot Temperature
Molecular and cellular biology
Mutation
Protein Kinases - metabolism
Saccharomyces cerevisiae - genetics
Transcription, Genetic
Title Heat shock-mediated cell cycle blockage and G1 cyclin expression in the yeast Saccharomyces cerevisiae
URI http://mcb.asm.org/content/13/2/1034.abstract
https://www.ncbi.nlm.nih.gov/pubmed/8380888
https://search.proquest.com/docview/75571009
https://pubmed.ncbi.nlm.nih.gov/PMC358988
Volume 13
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