Probing GABA Receptor Function in Schizophrenia with Iomazenil

• Published in: Neuropsychopharmacology (New York, N.Y.) Vol. 36; no. 3; pp. 677 - 683
• Main Authors: Ahn, Kyungheup, Gil, Roberto, Seibyl, John, Sewell, Richard Andrew, D'Souza, Deepak Cyril
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.02.2011; Nature Publishing Group
• Subjects: 631/378/1689/1761; 631/378/548/1964; 631/92/436/2387; 692/699/476/1799; Adult; Analysis of Variance; Anxiety - drug therapy; Anxiety - etiology; Behavioral Sciences; Benzodiazepines; Biological Psychology; Brief Psychiatric Rating Scale; Double-Blind Method; Flumazenil - analogs & derivatives; Humans; Hypotheses; Iodine Radioisotopes; Male; Medical imaging; Medicine; Medicine & Public Health; Middle Aged; Neuroimaging; Neurons; Neurosciences; Original; original-article; Pathophysiology; Pharmacotherapy; Psychiatry; Psychosis; Receptors, GABA - metabolism; Schizophrenia; Schizophrenia - complications; Schizophrenia - metabolism; United States > US; Connecticut; GABA; schizophrenia; iomazenil; psychosis

Several lines of evidence from post-mortem, brain imaging, and genetic studies in schizophrenia patients suggest that Gamma-amino butyric acid (GABA) deficits may contribute to the pathophysiology of schizophrenia. Pharmacological induction of a transient GABA-deficit state has been shown to enhance...