Pre-operative predictors of post-hepatectomy recurrence of hepatocellular carcinoma: Can we predict earlier?

Abstract Backgrounds and purpose To determine the predictors for recurrence in patients receiving curative hepatectomy for hepatocellular carcinoma (HCC). Methods From January 2001 to July 2007, all patients having hepatectomy for first occurrence HCC with curative intent were identified from a pros...

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Published inThe surgeon (Edinburgh) Vol. 10; no. 5; pp. 260 - 266
Main Authors Chong, Charing Ching-Ning, Lee, Kit-fai, Ip, Philip Ching-Tak, Wong, Jeff Siu-Wang, Cheung, Sunny Yue-Sun, Wong, John, Ho, Suzanne C, Lai, Paul Bo-San
Format Journal Article
LanguageEnglish
Published Scotland Elsevier Ltd 01.10.2012
Subjects
Adult
Aged
Carcinoma, Hepatocellular - mortality
Carcinoma, Hepatocellular - surgery
Female
Hepatectomy
Hepatocellular carcinoma
Humans
Kaplan-Meier Estimate
Liver Neoplasms - mortality
Liver Neoplasms - surgery
Male
Middle Aged
Multivariate Analysis
Neoplasm Recurrence, Local - diagnosis
Predictors
Prognosis
Recurrence
Retrospective Studies
Risk Factors
Surgery
Recurrence
Hepatocellular carcinoma
Hepatectomy
Predictors
Online AccessGet full text

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Abstract Abstract Backgrounds and purpose To determine the predictors for recurrence in patients receiving curative hepatectomy for hepatocellular carcinoma (HCC). Methods From January 2001 to July 2007, all patients having hepatectomy for first occurrence HCC with curative intent were identified from a prospectively collected database. Prognostic factors for recurrence and survival after resection were analyzed. Results A total of 235 patients were included. With a median follow-up of 50.2 (0.07–125.1) months, the recurrence rate was 57.0%. The 1-, 3-, and 5-year overall survival rates were 83.9%, 66.0%, and 58.1% respectively. Multivariate analysis demonstrated that multi-focal lesions (HR: 2.93, P  < 0.001), alpha-fetoprotein (AFP) level greater than 100 ng/ml (HR: 1.74, P  = 0.002) and history of tumor rupture (HR: 2.84, P  = 0.003) were independent risk factors for recurrence of HCC after hepatectomy. Conclusions Predictors for HCC recurrence can be identified before operation. These important parameters should be considered before and after contemplating curative resection for HCC patients and for risk stratification in future clinical trials for neoadjuvant or post-resection adjuvant therapy. The possible use of neoadjuvant or adjuvant treatment to improve survival should be addressed by further trials.
AbstractList BACKGROUNDS AND PURPOSETo determine the predictors for recurrence in patients receiving curative hepatectomy for hepatocellular carcinoma (HCC).METHODSFrom January 2001 to July 2007, all patients having hepatectomy for first occurrence HCC with curative intent were identified from a prospectively collected database. Prognostic factors for recurrence and survival after resection were analyzed.RESULTSA total of 235 patients were included. With a median follow-up of 50.2 (0.07-125.1) months, the recurrence rate was 57.0%. The 1-, 3-, and 5-year overall survival rates were 83.9%, 66.0%, and 58.1% respectively. Multivariate analysis demonstrated that multi-focal lesions (HR: 2.93, P < 0.001), alpha-fetoprotein (AFP) level greater than 100 ng/ml (HR: 1.74, P = 0.002) and history of tumor rupture (HR: 2.84, P = 0.003) were independent risk factors for recurrence of HCC after hepatectomy.CONCLUSIONSPredictors for HCC recurrence can be identified before operation. These important parameters should be considered before and after contemplating curative resection for HCC patients and for risk stratification in future clinical trials for neoadjuvant or post-resection adjuvant therapy. The possible use of neoadjuvant or adjuvant treatment to improve survival should be addressed by further trials.
To determine the predictors for recurrence in patients receiving curative hepatectomy for hepatocellular carcinoma (HCC). From January 2001 to July 2007, all patients having hepatectomy for first occurrence HCC with curative intent were identified from a prospectively collected database. Prognostic factors for recurrence and survival after resection were analyzed. A total of 235 patients were included. With a median follow-up of 50.2 (0.07–125.1) months, the recurrence rate was 57.0%. The 1-, 3-, and 5-year overall survival rates were 83.9%, 66.0%, and 58.1% respectively. Multivariate analysis demonstrated that multi-focal lesions (HR: 2.93, P < 0.001), alpha-fetoprotein (AFP) level greater than 100 ng/ml (HR: 1.74, P = 0.002) and history of tumor rupture (HR: 2.84, P = 0.003) were independent risk factors for recurrence of HCC after hepatectomy. Predictors for HCC recurrence can be identified before operation. These important parameters should be considered before and after contemplating curative resection for HCC patients and for risk stratification in future clinical trials for neoadjuvant or post-resection adjuvant therapy. The possible use of neoadjuvant or adjuvant treatment to improve survival should be addressed by further trials.
Abstract Backgrounds and purpose To determine the predictors for recurrence in patients receiving curative hepatectomy for hepatocellular carcinoma (HCC). Methods From January 2001 to July 2007, all patients having hepatectomy for first occurrence HCC with curative intent were identified from a prospectively collected database. Prognostic factors for recurrence and survival after resection were analyzed. Results A total of 235 patients were included. With a median follow-up of 50.2 (0.07–125.1) months, the recurrence rate was 57.0%. The 1-, 3-, and 5-year overall survival rates were 83.9%, 66.0%, and 58.1% respectively. Multivariate analysis demonstrated that multi-focal lesions (HR: 2.93, P  < 0.001), alpha-fetoprotein (AFP) level greater than 100 ng/ml (HR: 1.74, P  = 0.002) and history of tumor rupture (HR: 2.84, P  = 0.003) were independent risk factors for recurrence of HCC after hepatectomy. Conclusions Predictors for HCC recurrence can be identified before operation. These important parameters should be considered before and after contemplating curative resection for HCC patients and for risk stratification in future clinical trials for neoadjuvant or post-resection adjuvant therapy. The possible use of neoadjuvant or adjuvant treatment to improve survival should be addressed by further trials.
Author Cheung, Sunny Yue-Sun
Wong, John
Ho, Suzanne C
Wong, Jeff Siu-Wang
Lee, Kit-fai
Chong, Charing Ching-Ning
Ip, Philip Ching-Tak
Lai, Paul Bo-San
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Keywords Recurrence
Hepatocellular carcinoma
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Snippet Abstract Backgrounds and purpose To determine the predictors for recurrence in patients receiving curative hepatectomy for hepatocellular carcinoma (HCC)....
To determine the predictors for recurrence in patients receiving curative hepatectomy for hepatocellular carcinoma (HCC). From January 2001 to July 2007, all...
BACKGROUNDS AND PURPOSETo determine the predictors for recurrence in patients receiving curative hepatectomy for hepatocellular carcinoma (HCC).METHODSFrom...
SourceID proquest
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StartPage 260
SubjectTerms Adult
Aged
Carcinoma, Hepatocellular - mortality
Carcinoma, Hepatocellular - surgery
Female
Hepatectomy
Hepatocellular carcinoma
Humans
Kaplan-Meier Estimate
Liver Neoplasms - mortality
Liver Neoplasms - surgery
Male
Middle Aged
Multivariate Analysis
Neoplasm Recurrence, Local - diagnosis
Predictors
Prognosis
Recurrence
Retrospective Studies
Risk Factors
Surgery
Title Pre-operative predictors of post-hepatectomy recurrence of hepatocellular carcinoma: Can we predict earlier?
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https://dx.doi.org/10.1016/j.surge.2011.07.004
https://www.ncbi.nlm.nih.gov/pubmed/22959159
https://search.proquest.com/docview/1039040247
Volume 10
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