Developmental Toxicity of Mycotoxin Fumonisin B1 in Animal Embryogenesis: An Overview

• Published in: Toxins Vol. 11; no. 2; p. 114
• Main Authors: Lumsangkul, Chompunut, Chiang, Hsin-I, Lo, Neng-Wen, Fan, Yang-Kwang, Ju, Jyh-Cherng
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 13.02.2019; MDPI
• Subjects: Abnormalities; Animals; Biosynthesis; Ceramide; Contaminants; Defects; developmental toxicity; Embryogenesis; Embryonic Development - drug effects; Embryonic growth stage; Embryos; Fetuses; Folic acid; Food contamination & poisoning; Fumonisin B1; Fumonisins - pharmacokinetics; Fumonisins - toxicity; Growth rate; Hamsters; Hogs; Humans; Lipids; Metabolism; Metabolites; Mycotoxins; Neural tube defects; NTD; Placenta; Review; Sphinganine; Sphingolipids; teratogen; Teratogenicity; Toxicity; Vitamin B; Weaning; teratogen; Fumonisin B1; embryogenesis; developmental toxicity; NTD

A teratogenic agent or teratogen can disturb the development of an embryo or a fetus. Fumonisin B1 (FB1), produced by Fusarium verticillioides and F. proliferatum, is among the most commonly seen mycotoxins and contaminants from stale maize and other farm products. It may cause physical or functiona...