Decreased Fibronectin Production Significantly Contributes to Dysregulated Repair of Asthmatic Epithelium

• Published in: American journal of respiratory and critical care medicine Vol. 181; no. 9; pp. 889 - 898
• Main Authors: Kicic, Anthony, Hallstrand, Teal S., Sutanto, Erika N., Stevens, Paul T., Kobor, Michael S., Taplin, Christopher, Paré, Peter D., Beyer, Richard P., Stick, Stephen M., Knight, Darryl A.
• Format: Journal Article
• Language: English
• Published: New York, NY American Thoracic Society 01.05.2010
• Subjects: A. Asthma and Allergy; Adolescent; Anesthesia; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Asthma; Asthma - physiopathology; Azacitidine - pharmacology; Biological and medical sciences; Cells, Cultured; Child; Child, Preschool; Cycloheximide - pharmacology; Cytokines; Dexamethasone - pharmacology; DNA Methylation; Enzyme-Linked Immunosorbent Assay; Epithelial Cells - drug effects; Epithelial Cells - physiology; Extracellular matrix; Extracellular Matrix - metabolism; Fibronectins - biosynthesis; Gene expression; Growth factors; Homocysteine; Homocystine - pharmacology; Humans; Hydroxamic Acids - pharmacology; Hypersensitivity - physiopathology; Intensive care medicine; Local anesthesia. Pain (treatment); Medical sciences; Microarray Analysis; Polymerase chain reaction; Respiratory Mucosa - physiopathology; Tetradecanoylphorbol Acetate - pharmacology; Transforming Growth Factor beta1 - pharmacology; Germany; Lung disease; Intensive care; wound repair; Respiratory disease; Bronchus disease; Inflammation; Obstructive pulmonary disease; Epithelium; Wound; Fibronectin; Resuscitation; Asthma

Damage to airway epithelium is followed by deposition of extracellular matrix (ECM) and migration of adjacent epithelial cells. We have shown that epithelial cells from children with asthma fail to heal a wound in vitro. To determine whether dysregulated ECM production by the epithelium plays a role...