Effects of Propranolol on the Transmembrane Potentials of Ventricular Muscle and Purkinje Fibers of the Dog

• Published in: Circulation research Vol. 22; no. 5; pp. 661 - 677
• Main Authors: DAVIS, LARRY D, TEMTE, JOHN V
• Format: Journal Article
• Language: English
• Published: United States American Heart Association, Inc 01.05.1968
• Subjects: Animals; Arrhythmias, Cardiac; Dogs; Electric Stimulation; Electrophysiology; Epinephrine - pharmacology; Heart - physiology; Heart Conduction System - drug effects; Heart Ventricles - drug effects; Membrane Potentials - drug effects; Propranolol - pharmacology; Tachycardia; Ventricular Fibrillation

Papillary muscle-false tendon tissue preparations isolated from dog hearts were perfused with Tyrodeʼs solution containing propranolol in concentrations ranging from 0.1 to 20.0 mg/liter. Transmembrane action potentials of both ventricular muscle fibers and Purkinje fibers were recorded. With suffic...