Resistance/susceptibility to Echinococcus multilocularis infection and cytokine profile in humans. II. Influence of the HLA B8, DR3, DQ2 haplotype

• Published in: Clinical and experimental immunology Vol. 121; no. 3; pp. 491 - 498
• Main Authors: Godot, V., Harraga, S., Beurton, I., Tiberghien, P., Sarciron, E., Gottstein, B., Vuitton, D. A.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01.09.2000; Blackwell; Blackwell Science Inc
• Subjects: alveolar echinococcosis; Animals; Antigens, Helminth - administration & dosage; Antigens, Helminth - isolation & purification; Biological and medical sciences; Case-Control Studies; cellular immunity; Cytokines - genetics; Cytokines - metabolism; Diseases caused by cestodes; Echinococcoses; Echinococcosis - etiology; Echinococcosis - genetics; Echinococcosis - immunology; Echinococcus - immunology; Echinococcus multilocularis; g-Interferon; Haplotypes; Helminthic diseases; histocompatibility locus HLA; HLA Antigens - genetics; HLA-B8 Antigen - genetics; HLA-DQ Antigens - genetics; HLA-DR3 Antigen - genetics; Humans; IL‐10; IL‐5; Immunity to Infection; In Vitro Techniques; Infectious diseases; Interferon-gamma - genetics; Interferon-gamma - metabolism; interferon‐gamma; Interleukin-10 - genetics; Interleukin-10 - metabolism; Interleukin-5 - genetics; Interleukin-5 - metabolism; Leukocytes, Mononuclear - immunology; Medical sciences; Parasitic diseases; RNA, Messenger - genetics; RNA, Messenger - metabolism; Th2 Cells - immunology; Tumor Necrosis Factor-alpha - metabolism; tumour necrosis factor; Human; HLA-System; Immune response; Major histocompatibility system; Cytokine; Class II histocompatibility antigen; Plathelmintha; Hepatic disease; Cellular immunity; Parasitosis; Cestoda; Helminthiasis; Cestode disease; Infection; Echinococcus multilocularis; Interleukin 5; Risk factor; Interleukin 10; Helmintha; Digestive diseases; Invertebrata; Echinococciasis; Haplotype; Gamma interferon

Differences have been shown between HLA characteristics of patients with different courses of alveolar echinococcosis (AE). Notably the HLA B8, DR3, DQ2 haplotype was associated with more severe forms of this granulomatous parasitic disease. We compared IL‐10, IL‐5, interferon‐gamma (IFN‐γ) and tumo...