Initiating and potentiating role of platelets in tissue factor‐induced thrombin generation in the presence of plasma: subject‐dependent variation in thrombogram characteristics

• Published in: Journal of thrombosis and haemostasis Vol. 2; no. 3; pp. 476 - 484
• Main Authors: Vanschoonbeek, K., Feijge, M. A. H., Van Kampen, R. J. W., Kenis, H., Hemker, H. C., Giesen, P. L. A., Heemskerk, J. W. M.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Inc 01.03.2004
• Subjects: Blood Platelets - physiology; coagulation; Female; Humans; Kinetics; Male; phosphatidylserine; Phospholipids - blood; platelets; Reference Values; thrombin; Thrombin - metabolism; Thromboplastin - physiology

The hemostatic activity of plasma is determined by platelet activation and coagulation, which processes are mutually stimulatory. We studied this interaction by measuring the cleavage of fluorescent thrombin substrate in platelet‐rich plasma (PRP), using the calibrated thrombogram method. In freshly...