Detergent Insoluble Proteins and Inclusion Body-Like Structures Immunoreactive for PRKDC/DNA-PK/DNA-PKcs, FTL, NNT, and AIFM1 in the Amygdala of Cognitively Impaired Elderly Persons

• Published in: Journal of neuropathology and experimental neurology Vol. 77; no. 1; pp. 21 - 39
• Main Authors: Gal, Jozsef, Chen, Jing, Katsumata, Yuriko, Fardo, David W, Wang, Wang-Xia, Artiushin, Sergey, Price, Douglas, Anderson, Sonya, Patel, Ela, Zhu, Haining, Nelson, Peter T
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.01.2018; by American Association of Neuropathologists, Inc
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Amygdala - metabolism; Amygdala - pathology; Apoferritins - metabolism; Apoptosis Inducing Factor - metabolism; Chromatography, Liquid; Cognitive Dysfunction - metabolism; Cognitive Dysfunction - pathology; Deoxyribonucleic acid; DNA; DNA-Activated Protein Kinase - metabolism; DNA-Binding Proteins - metabolism; Humans; Inclusion Bodies - metabolism; Inclusion Bodies - pathology; Ions; Mitochondrial Proteins - metabolism; Molecular weight; NADP Transhydrogenase, AB-Specific - metabolism; Nuclear Proteins - metabolism; Original; Proteins; Proteomics; Tandem Mass Spectrometry; LC-MS; Phosphorylation; GWAS; Proteomics; Tauopathy; ADSP; Lewy

Abstract Misfolded protein in the amygdala is a neuropathologic feature of Alzheimer disease and many other neurodegenerative disorders. We examined extracts from human amygdala (snap-frozen at autopsy) to investigate whether novel and as yet uncharacterized misfolded proteins would be detectable. P...