Plantago major treatment enhanced innate antioxidant activity in experimental acetaminophen toxicity
Objective: To determine the ef ect of Plantago major(P. major) extract on the liver injury following acetaminophen(APAP) toxicity. Methods: The male Sprague Dawley rats(n = 38) were randomly divided into normal control(n = 6) and experiment(n = 32) groups. The latter was subdivided into four groups...
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Published in | Asian Pacific journal of tropical biomedicine Vol. 5; no. 9; pp. 703 - 707 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
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Elsevier B.V
01.09.2015
Wolters Kluwer Medknow Publications |
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Abstract | Objective: To determine the ef ect of Plantago major(P. major) extract on the liver injury following acetaminophen(APAP) toxicity. Methods: The male Sprague Dawley rats(n = 38) were randomly divided into normal control(n = 6) and experiment(n = 32) groups. The latter was subdivided into four groups and induced with APAP(1 000 mg/kg) per oral, followed by P. major extract and N-acetylcysteine orally to the respective groups for six days. Results: On the seventh day, the serum bilirubin, liver enzymes and tissue malondialdehyde were increased in APAP groups whereas the total protein in serum, tissue superoxide dismutase and glutathione levels were reduced. The plant extract treatment reduced the histological deteriorations such as aggregation of hepatocellular cords, formation of binucleated cells and vacuolisation of the cells with scanty cytoplasm. It also revealed signii cant reduction of malondialdehyde and increased level of superoxide dismutase and glutathione. The i ndings in the extract treated groups were comparable to the group treated with N-acetylcysteine. Conclusions: In conclusion, P. major can enhance innate antioxidant activity and ameliorate the APAP-induced liver injury. |
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AbstractList | To determine the effect of Plantago major (P. major) extract on the liver injury following acetaminophen (APAP) toxicity.
The male Sprague Dawley rats (n = 38) were randomly divided into normal control (n = 6) and experiment (n = 32) groups. The latter was subdivided into four groups and induced with APAP (1000 mg/kg) per oral, followed by P. major extract and N-acetylcysteine orally to the respective groups for six days.
On the seventh day, the serum bilirubin, liver enzymes and tissue malondialdehyde were increased in APAP groups whereas the total protein in serum, tissue superoxide dismutase and glutathione levels were reduced. The plant extract treatment reduced the histological deteriorations such as aggregation of hepatocellular cords, formation of binucleated cells and vacuolisation of the cells with scanty cytoplasm. It also revealed significant reduction of malondialdehyde and increased level of superoxide dismutase and glutathione. The findings in the extract treated groups were comparable to the group treated with N-acetylcysteine.
In conclusion, P. major can enhance innate antioxidant activity and ameliorate the APAP-induced liver injury. Objective: To determine the effect of Plantago major (P. major) extract on the liver injury following acetaminophen (APAP) toxicity. Methods: The male Sprague Dawley rats (n = 38) were randomly divided into normal control (n = 6) and experiment (n = 32) groups. The latter was subdivided into four groups and induced with APAP (1000 mg/kg) per oral, followed by P. major extract and N-acetylcysteine orally to the respective groups for six days. Results: On the seventh day, the serum bilirubin, liver enzymes and tissue malondialdehyde were increased in APAP groups whereas the total protein in serum, tissue superoxide dismutase and glutathione levels were reduced. The plant extract treatment reduced the histological deteriorations such as aggregation of hepatocellular cords, formation of binucleated cells and vacuolisation of the cells with scanty cytoplasm. It also revealed significant reduction of malondialdehyde and increased level of superoxide dismutase and glutathione. The findings in the extract treated groups were comparable to the group treated with N-acetylcysteine. Conclusions: In conclusion, P. major can enhance innate antioxidant activity and ameliorate the APAP-induced liver injury. Objective: To determine the ef ect of Plantago major(P. major) extract on the liver injury following acetaminophen(APAP) toxicity. Methods: The male Sprague Dawley rats(n = 38) were randomly divided into normal control(n = 6) and experiment(n = 32) groups. The latter was subdivided into four groups and induced with APAP(1 000 mg/kg) per oral, followed by P. major extract and N-acetylcysteine orally to the respective groups for six days. Results: On the seventh day, the serum bilirubin, liver enzymes and tissue malondialdehyde were increased in APAP groups whereas the total protein in serum, tissue superoxide dismutase and glutathione levels were reduced. The plant extract treatment reduced the histological deteriorations such as aggregation of hepatocellular cords, formation of binucleated cells and vacuolisation of the cells with scanty cytoplasm. It also revealed signii cant reduction of malondialdehyde and increased level of superoxide dismutase and glutathione. The i ndings in the extract treated groups were comparable to the group treated with N-acetylcysteine. Conclusions: In conclusion, P. major can enhance innate antioxidant activity and ameliorate the APAP-induced liver injury. |
Author | Farida Hussan Rina Haryani Osman Basah Mohd Rai zul Mohd Yusof Nur Aqilah Kamaruddin Faizah Othman |
AuthorAffiliation | Anatomy Department, Faculty of Medicine, Universiti Kebangsaan Malaysia |
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CitedBy_id | crossref_primary_10_1371_journal_pone_0298518 crossref_primary_10_1007_s42690_024_01208_6 crossref_primary_10_1155_2021_6693887 crossref_primary_10_1016_j_ijbiomac_2021_09_115 |
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Keywords | Antioxidants Oxidative stress Plantago major Acetaminophen Liver injury |
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Notes | Farida Hussan;Rina Haryani Osman Basah;Mohd Rai zul Mohd Yusof;Nur Aqilah Kamaruddin;Faizah Othman;Anatomy Department, Faculty of Medicine, Universiti Kebangsaan Malaysia |
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Snippet | Objective: To determine the ef ect of Plantago major(P. major) extract on the liver injury following acetaminophen(APAP) toxicity. Methods: The male Sprague... To determine the effect of Plantago major (P. major) extract on the liver injury following acetaminophen (APAP) toxicity. The male Sprague Dawley rats (n = 38)... Objective: To determine the effect of Plantago major (P. major) extract on the liver injury following acetaminophen (APAP) toxicity. Methods: The male Sprague... |
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SubjectTerms | Acetaminophen Antioxidants injury Liver Liver injury major Oxidative Oxidative stress Plantago Plantago major stress |
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Title | Plantago major treatment enhanced innate antioxidant activity in experimental acetaminophen toxicity |
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