Concomitant vascular and neurodegenerative pathologies double the risk of dementia

• Published in: Alzheimer's & dementia Vol. 14; no. 2; pp. 148 - 156
• Main Authors: Azarpazhooh, Mahmoud Reza, Avan, Abolfazl, Cipriano, Lauren E., Munoz, David G., Sposato, Luciano A., Hachinski, Vladimir
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2018
• Subjects: Aged; Aged, 80 and over; Aging; Alzheimer's disease; Cohort Studies; Databases, Bibliographic - statistics & numerical data; Dementia - etiology; Female; Humans; Macroinfarct; Male; Meta-analysis; Microinfarct; Middle Aged; Mixed dementia; Neurodegenerative Diseases - complications; Neurodegenerative Diseases - pathology; Plaques; Prevention; Risk; Systematic review; Tangles; Vascular cognitive impairment; Vascular dementia; Vascular Diseases - complications; Vascular Diseases - pathology; Vascular dementia; Mixed dementia; Tangles; Risk; Systematic review; Meta-analysis; Macroinfarct; Prevention; Microinfarct; Vascular cognitive impairment; Aging; Alzheimer's disease; Plaques

The relative contributions of vascular and degenerative pathology to dementia are unknown. We aim to quantify the proportion of dementia explained by potentially preventable vascular lesions. We systematically searched for population-based cohorts before February 2017 reporting clinicopathological d...