Clinical significance of glutamic acid decarboxylase antibodies in patients with epilepsy

• Published in: Epilepsia (Copenhagen) Vol. 51; no. 5; pp. 760 - 767
• Main Authors: Liimatainen, Suvi, Peltola, Maria, Sabater, Lidia, Fallah, Mahdi, Kharazmi, Elham, Haapala, Anna‐Maija, Dastidar, Prasun, Knip, Mikael, Saiz, Albert, Peltola, Jukka
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.05.2010; Wiley-Blackwell
• Subjects: Adolescent; Adult; Age Distribution; Aged; Anticonvulsants. Antiepileptics. Antiparkinson agents; Autoantibodies - blood; Autoantibodies - cerebrospinal fluid; Autoantibodies - immunology; Autoimmune Diseases - blood; Autoimmune Diseases - diagnosis; Autoimmune Diseases - immunology; Biological and medical sciences; Blotting, Western; Epilepsy - blood; Epilepsy - cerebrospinal fluid; Epilepsy - immunology; Epilepsy, Temporal Lobe - blood; Epilepsy, Temporal Lobe - immunology; Female; Genetic Markers; Glutamate Decarboxylase - blood; Glutamate Decarboxylase - immunology; Glutamic acid decarboxylase antibody; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy; Humans; Immune system; Immunohistochemistry; Male; Medical sciences; Middle Aged; Nervous system (semeiology, syndromes); Neurology; Neuropharmacology; Pharmacology. Drug treatments; Polyendocrinopathies, Autoimmune - diagnosis; Polyendocrinopathies, Autoimmune - immunology; Polyendocrinopathy; Radioimmunoassay; Temporal lobe epilepsy; Human; Glutamic acid; Nervous system diseases; Aminoacid; Central nervous system disease; Complex partial epilepsy; Temporal lobe epilepsy; Polyendocrinopathy; Glutamic acid decarboxylase antibody; Cerebral disorder; Immune system

Summary Purpose:  Glutamic acid decarboxylase antibodies (GADAs) have been detected in patients with epilepsy, but the clinical determinants of epilepsy associated with GADA have not been defined. Methods:  We analyzed GADA with a radioimmunoassay in sera of 253 well‐characterized patients with epil...