Efficacy and safety of eslicarbazepine acetate as add‐on treatment in patients with focal‐onset seizures: Integrated analysis of pooled data from double‐blind phase III clinical studies

• Published in: Epilepsia (Copenhagen) Vol. 54; no. 1; pp. 98 - 107
• Main Authors: Gil‐Nagel, António, Elger, Christian, Ben‐Menachem, Elinor, Halász, Peter, Lopes‐Lima, José, Gabbai, Alberto A., Nunes, Teresa, Falcão, Amílcar, Almeida, Luis, Soares‐da‐Silva, Patrício
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.01.2013; Wiley Subscription Services, Inc
• Subjects: Acetic acid; Adjunctive therapy; Adult; Adults; Age; Anticonvulsants - administration & dosage; Anticonvulsants - adverse effects; Anticonvulsants - therapeutic use; Antiepileptic agents; Antiepileptic drugs; Clinical trials; Data processing; Dibenzazepines - administration & dosage; Dibenzazepines - adverse effects; Dibenzazepines - therapeutic use; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Epilepsies, Partial - drug therapy; Epilepsy; Eslicarbazepine acetate; Female; Headache; Humans; Male; Partial‐onset seizures; Population studies; Refractory epilepsy; Seizures; Subpopulations; Titration

Summary Purpose:  To evaluate the efficacy and safety profile of eslicarbazepine acetate (ESL) added to stable antiepileptic therapy in adults with partial‐onset seizures. Methods:  Data from 1,049 patients enrolled from 125 centers, in 23 countries, in three phase III double‐blind, randomized, plac...