Prefrontal Glutamate Neurotransmission in PTSD: A Novel Approach to Estimate Synaptic Strength in Vivo in Humans

• Published in: Chronic stress (Thousand Oaks, Calif.) Vol. 6; p. 24705470221092734
• Main Authors: Averill, Lynnette A., Jiang, Lihong, Purohit, Prerana, Coppoli, Anastasia, Averill, Christopher L., Roscoe, Jeremy, Kelmendi, Benjamin, De Feyter, Henk M., de Graaf, Robin A, Gueorguieva, Ralitza, Sanacora, Gerard, Krystal, John H., Rothman, Douglas L., Mason, Graeme F., Abdallah, Chadi G.
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.01.2022; Sage Publications Ltd; SAGE Publishing
• Subjects: Original; Post traumatic stress disorder; Psychopathology; PTSD; synaptic strength; trauma; stress; depression; glutamate

Background Trauma and chronic stress are believed to induce and exacerbate psychopathology by disrupting glutamate synaptic strength. However, in vivo in human methods to estimate synaptic strength are limited. In this study, we established a novel putative biomarker of glutamatergic synaptic streng...