Levodopa‐induced dyskinesia in Parkinson disease: Current and evolving concepts

• Published in: Annals of neurology Vol. 84; no. 6; pp. 797 - 811
• Main Authors: Espay, Alberto J., Morgante, Francesca, Merola, Aristide, Fasano, Alfonso, Marsili, Luca, Fox, Susan H., Bezard, Erwan, Picconi, Barbara, Calabresi, Paolo, Lang, Anthony E.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.12.2018
• Subjects: Acetylcholine receptors (nicotinic); Axons; Cortex; Dopamine; Dopamine receptors; Dyskinesia; Glutamatergic transmission; Hyperactivity; Levodopa; Movement disorders; Neurodegenerative diseases; Parkinson's disease; Receptors; Serotonin

Levodopa‐induced dyskinesia is a common complication in Parkinson disease. Pathogenic mechanisms include phasic stimulation of dopamine receptors, nonphysiological levodopa‐to‐dopamine conversion in serotonergic neurons, hyperactivity of corticostriatal glutamatergic transmission, and overstimulatio...