Pathological correlations of [F‐18]‐AV‐1451 imaging in non‐alzheimer tauopathies

• Published in: Annals of neurology Vol. 81; no. 1; pp. 117 - 128
• Main Authors: Marquié, Marta, Normandin, Marc D., Meltzer, Avery C., Siao Tick Chong, Michael, Andrea, Nicolas V., Antón‐Fernández, Alejandro, Klunk, William E., Mathis, Chester A., Ikonomovic, Milos D., Debnath, Manik, Bien, Elizabeth A., Vanderburg, Charles R., Costantino, Isabel, Makaretz, Sara, DeVos, Sarah L., Oakley, Derek H., Gomperts, Stephen N., Growdon, John H., Domoto‐Reilly, Kimiko, Lucente, Diane, Dickerson, Bradford C., Frosch, Matthew P., Hyman, Bradley T., Johnson, Keith A., Gómez‐Isla, Teresa
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.01.2017
• Subjects: Affinity; Age; Aged; Alzheimer's disease; Autopsies; Autopsy; Autoradiography; Axons; Basal ganglia; Binding; Brain; Brain - diagnostic imaging; Brain - metabolism; Brain - pathology; Carbolines - metabolism; Cortex (entorhinal); Emission analysis; Filaments; Fluorine isotopes; Fluorine Radioisotopes - metabolism; Functional Neuroimaging; Ganglia; Grain; Humans; In vivo methods and tests; Lesions; Ligands; Male; Medical imaging; Mesencephalon; Middle Aged; Mutation; Neurodegenerative diseases; Neurofibrillary tangles; Neuroimaging; Paralysis; Positron emission; Positron emission tomography; Progressive supranuclear palsy; Radioisotopes; Radioligand Assay; Retention; Substantia alba; Substantia nigra; Supranuclear Palsy, Progressive - diagnostic imaging; Supranuclear Palsy, Progressive - pathology; Tau protein; tau Proteins - genetics; tau Proteins - metabolism; Tauopathies - diagnostic imaging; Tauopathies - metabolism; Tauopathies - pathology; Tomography; Tritium - metabolism

Objective Recent studies have shown that positron emission tomography (PET) tracer AV‐1451 exhibits high binding affinity for paired helical filament (PHF)‐tau pathology in Alzheimer's brains. However, the ability of this ligand to bind to tau lesions in other tauopathies remains controversial....