Effects of short‐term mild hypercapnia during head‐down tilt on intracranial pressure and ocular structures in healthy human subjects

• Published in: Physiological reports Vol. 5; no. 11
• Main Authors: Laurie, Steven S., Vizzeri, Gianmarco, Taibbi, Giovanni, Ferguson, Connor R., Hu, Xiao, Lee, Stuart M. C., Ploutz‐Snyder, Robert, Smith, Scott M., Zwart, Sara R., Stenger, Michael B.
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.06.2017; John Wiley and Sons Inc
• Subjects: Acuity; Adult; Carbon dioxide; Distension; Edema; Environmental Physiology; Fluid Shifts - physiology; Functional anatomy; Head-Down Tilt - physiology; Head‐down tilt; Humans; Hypercapnia; Hypercapnia - physiopathology; Intracranial Pressure - physiology; Intraocular Pressure - physiology; Male; Metabolism and Regulation; Middle Aged; NASA; one‐carbon metabolism; Optic nerve; Original Research; Physiology; Pressure; Respiratory Conditions Disorder and Diseases; Retina; Sensory Neuroscience; Space Flight; Structure-function relationships; Tomography; Tomography, Optical Coherence; translaminar pressure difference; Ultrasound; Weightlessness; Weightlessness Simulation; translaminar pressure difference; one‐carbon metabolism; NASA; hypercapnia; Head‐down tilt

Many astronauts experience ocular structural and functional changes during long‐duration spaceflight, including choroidal folds, optic disc edema, globe flattening, optic nerve sheath diameter (ONSD) distension, retinal nerve fiber layer thickening, and decreased visual acuity. The leading hypothesi...