CXCR4 is required for the quiescence of primitive hematopoietic cells

• Published in: The Journal of experimental medicine Vol. 205; no. 4; pp. 777 - 783
• Main Authors: Nie, Yuchun, Han, Yoon-Chi, Zou, Yong-Rui
• Format: Journal Article
• Language: English
• Published: United States The Rockefeller University Press 14.04.2008
• Subjects: Animals; Bone Marrow Cells - cytology; Brief Definitive Reports; Cell Cycle; Cell Proliferation; Chemokine CXCL12 - metabolism; Hematopoiesis; Hematopoietic Stem Cells - cytology; Hematopoietic System - cytology; Mice; Multipotent Stem Cells - cytology; Receptors, CXCR4 - deficiency; Receptors, CXCR4 - metabolism; Signal Transduction

The quiescence of hematopoietic stem cells (HSCs) is critical for preserving a lifelong steady pool of HSCs to sustain the highly regenerative hematopoietic system. It is thought that specialized niches in which HSCs reside control the balance between HSC quiescence and self-renewal, yet little is k...