HPV integration generates a cellular super-enhancer which functions as ecDNA to regulate genome-wide transcription

• Published in: Nucleic acids research Vol. 51; no. 9; pp. 4237 - 4251
• Main Authors: Tian, Rui, Huang, Zheying, Li, Lifang, Yuan, Jingping, Zhang, Qinghua, Meng, Lirong, Lang, Bin, Hong, Yongfeng, Zhong, Chaoyue, Tian, Xun, Cui, Zifeng, Jin, Zhuang, Liu, Jiashuo, Huang, Zhaoyue, Wang, Yuyan, Chen, Ye, Hu, Zheng
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 22.05.2023
• Subjects: Carcinogenesis; Chromosome Breakpoints; Chromosomes, Human - genetics; DNA - genetics; DNA - metabolism; Enhancer Elements, Genetic - genetics; Female; Gene regulation, Chromatin and Epigenetics; Genome, Human - genetics; Human Papillomavirus Viruses - genetics; Humans; Papillomavirus Infections - genetics; Papillomavirus Infections - virology; Transcription, Genetic; Uterine Cervical Neoplasms - genetics; Uterine Cervical Neoplasms - pathology; Uterine Cervical Neoplasms - virology; Virus Integration - genetics

Abstract Human papillomavirus (HPV) integration is a critical step in cervical cancer development; however, the oncogenic mechanism at the genome-wide transcriptional level is still poorly understood. In this study, we employed integrative analysis on multi-omics data of six HPV-positive and three H...