Higher level of faecal SCFA in women correlates with metabolic syndrome risk factors

• Published in: British journal of nutrition Vol. 109; no. 5; pp. 914 - 919
• Main Authors: Teixeira, Tatiana F. S., Grześkowiak, Łukasz, Franceschini, Sylvia C. C., Bressan, Josefina, Ferreira, Célia L. L. F., Peluzio, Maria C. G.
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 14.03.2013
• Subjects: Adiposity; Adult; Biological and medical sciences; blood glucose; Blood Glucose - analysis; Blood Pressure; Body Composition; Body Mass Index; Cholesterol, HDL - blood; Diet; energy; Energy Intake; Fatty acids; Fatty Acids, Volatile - analysis; Feces; Feces - chemistry; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; glucose; high density lipoprotein; homeostasis; Human and Clinical Nutrition; Humans; insulin; Insulin - blood; Insulin Resistance; Medical sciences; Metabolic diseases; Metabolic disorders; Metabolic syndrome; Metabolic Syndrome - metabolism; metabolism; Obesity; Obesity - metabolism; Risk Factors; short chain fatty acids; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Waist Circumference; women; Womens health; Obesity; HDL; SCFA; Insulin; Homeostasis model assessment; Human; Pancreatic hormone; Nutrition; Nutrition disorder; Homeostasis; Metabolic disorder; Female; Models; Feces; Nutritional status
• DOI: 10.1017/S0007114512002723
• ISSN: 0007-1145; 1475-2662

SCFA provide energy to the host and influence lipid and glucose metabolism, suggesting that they may have an impact on the occurrence of metabolic risk factors. The aim of the present study was to determine the concentration of SCFA in faeces of lean and obese individuals and to analyse whether associations between faecal SCFA and metabolic syndrome parameters are present. Lean (n 20) and obese (n 20) women of similar age (28·5 (sd 7·6) v. 30·7 (sd 6·5) years, P= 0·33) participated in the study. Anthropometric measurements, body composition, blood pressure and biochemical parameters were assessed. SCFA were extracted from faeces and quantified by GC. Blood pressure and blood glucose, although within the normal limits, were higher in the obese group compared to lean subjects (P< 0·05). Lower HDL concentration and higher insulin and homeostasis model assessment (HOMA) index were observed in the obese than in the lean group (P< 0·05). The median values of SCFA (% w/w) from the lean and obese groups were butyric (0·021 v. 0·044, P= 0·024), propionic (0·021 v. 0·051, P= 0·007) and acetic (0·03 v. 0·061, P= 0·01). SCFA correlated positively with metabolic syndrome risk factors such as adiposity, waist circumference and HOMA index (P< 0·05), and inversely with HDL (P< 0·05). Our results suggest that the higher faecal concentration of SCFA is associated with metabolic risk factors and thus may influence metabolic homeostasis.