Increased matrix metalloproteinase 2 expression in vascular smooth muscle cells cultured from abdominal aortic aneurysms

• Published in: Journal of vascular surgery Vol. 32; no. 3; pp. 575 - 583
• Main Authors: Crowther, Mathew, Goodall, Stephen, Jones, J.Louise, Bell, Peter R.F., Thompson, Matthew M.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.09.2000; Elsevier
• Subjects: Aged; Aged, 80 and over; Aortic Aneurysm, Abdominal - genetics; Aortic Aneurysm, Abdominal - pathology; Aortic Diseases - genetics; Aortic Diseases - pathology; Arteriosclerosis - genetics; Arteriosclerosis - pathology; Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Cells, Cultured; Diseases of the aorta; Female; Gene Expression Regulation, Enzymologic; Humans; Male; Matrix Metalloproteinase 2 - genetics; Medical sciences; Middle Aged; Muscle, Smooth, Vascular - pathology; Reference Values; Human; Cell culture; Enzyme; Pathogenesis; Aneurysm; Cardiovascular disease; Metalloendopeptidases; Smooth muscle; Gelatinase A; Arterial disease; Vascular disease; Abdominal aorta; Peptidases; Hydrolases; Aortic disease

Objectives: Recent evidence has implicated matrix metalloproteinase 2 (MMP-2) in the pathogenesis of aneurysms. The aim of this study was to examine MMP-2 production and expression by aortic smooth muscle cells (SMCs) and dermal fibroblasts derived from patients with abdominal aortic aneurysms (AAAs...