Itraconazole Nanosuspensions via Dual Centrifugation Media Milling: Impact of Formulation and Process Parameters on Particle Size and Solid-State Conversion as Well as Storage Stability

• Published in: Pharmaceutics Vol. 14; no. 8; p. 1528
• Main Authors: Willmann, Ann-Cathrin, Berkenfeld, Kai, Faber, Thilo, Wachtel, Herbert, Boeck, Georg, Wagner, Karl G
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 22.07.2022; MDPI
• Subjects: agglomeration; Cellulose acetate; Centrifugation; Chemical properties; Dosage and administration; Drug delivery systems; Drugs; dual centrifugation; Investigations; Itraconazole; media milling; nanocrystals; Nanoparticles; nanosuspension; Particle size; Pharmaceuticals; Stabilizing agents; Surfactants; Suspensions (Chemistry); Vehicles; Germany; United States > US

Nanocrystal suspensions proved to be a potent enabling principle for biopharmaceutics classification system class II drugs with dissolution limited bioavailability. In the example of itraconazole (ITZ) as a model drug combined with electrosteric stabilization using hydroxypropyl cellulose (HPC-SL),...