Organic cation transporter 3 modulates murine basophil functions by controlling intracellular histamine levels

• Published in: The Journal of experimental medicine Vol. 202; no. 3; pp. 387 - 393
• Main Authors: Schneider, Elke, Machavoine, François, Pléau, Jean-Marie, Bertron, Anne-France, Thurmond, Robin L, Ohtsu, Hiroshi, Watanabe, Takehiko, Schinkel, Alfred H, Dy, Michel
• Format: Journal Article
• Language: English
• Published: United States The Rockefeller University Press 01.08.2005
• Subjects: Animals; Basophils - cytology; Basophils - metabolism; Biological Transport, Active - genetics; Biological Transport, Active - physiology; Brief Definitive Report; Cytokines - metabolism; Histamine - metabolism; Histamine Release - genetics; Histamine Release - physiology; Histidine Decarboxylase - genetics; Histidine Decarboxylase - metabolism; Hypersensitivity - genetics; Hypersensitivity - metabolism; Mice; Mice, Knockout; Organic Cation Transport Proteins - genetics; Organic Cation Transport Proteins - metabolism; Receptors, Histamine H3 - metabolism

In this study, we identify the bidirectional organic cation transporter 3 (OCT3/Slc22a3) as the molecule responsible for histamine uptake by murine basophils. We demonstrate that OCT3 participates in the control of basophil functions because exogenous histamine can inhibit its own synthesis--and tha...