Nucleophosmin 1: from its pathogenic role to a tantalizing therapeutic target in acute myeloid leukemia

• Published in: Hematology (Luxembourg) Vol. 27; no. 1; pp. 609 - 619
• Main Authors: Shi, Yuye, Xue, Yuhao, Wang, Chunling, Yu, Liang
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 31.12.2022; Taylor & Francis Group
• Subjects: Acute myeloid leukemia; Adult; Apoptosis; Humans; Leukemia, Myeloid, Acute - drug therapy; Leukemia, Myeloid, Acute - genetics; Leukemia, Myeloid, Acute - pathology; leukemic pathogenesis; Mutation; Nuclear Proteins - genetics; Nucleophosmin; nucleophosmin 1; somatic mutation; therapeutic target; leukemic pathogenesis; therapeutic target; nucleophosmin 1; somatic mutation; Acute myeloid leukemia

Nucleophosmin 1 (NPM1, also known as B23) is a multifunctional protein involved in a variety of cellular processes, including ribosomal maturation, centrosome replication, maintenance of genomic stability, cell cycle control, and apoptosis. NPM1 is the most commonly mutated gene in adult acute myelo...