PKQuest: PBPK modeling of highly lipid soluble and extracellular solutes

• Published in: ADMET & DMPK Vol. 7; no. 1; pp. 60 - 75
• Main Author: Levitt, David G.
• Format: Journal Article Paper
• Language: English
• Published: Croatia Međunarodna udruga fizikalnih kemičara 01.01.2019; International Association of Physical Chemists; International Association of Physical Chemists (IAPC)
• Subjects: adipose; anesthetics; extracellular; interstitial; Original Scientific Paper; pharmacokinetics; pharmacokinetics; extracellular; adipose; anesthetics; interstitial

One of the primary objectives of physiologically based pharmacokinetics (PBPK) is the prediction of a drug’s pharmacokinetics just from knowledge of its physicochemical structure. Unfortunately, at present, the accuracy of this prediction is limited for most drugs because of uncertainty about the dr...