Nanoparticles-Based Strategies to Improve the Delivery of Therapeutic Small Interfering RNA in Precision Oncology

• Published in: Pharmaceutics Vol. 14; no. 8; p. 1586
• Main Authors: Huang, Jinxing, Xiao, Kai
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 29.07.2022; MDPI
• Subjects: Cancer; Cancer therapies; Care and treatment; Clinical trials; combination strategies; Drug resistance; Endothelium; FDA approval; gene delivery; Gene expression; Genes; Health aspects; Immunotherapy; Kinases; Ligands; Lipids; Liver cancer; Medical research; Methods; Nanoparticles; Patient compliance; Pharmaceutical industry; Proteins; Review; small interfering RNA; targeting; Tumors; Vascular endothelial growth factor; Vectors (Biology); China

Small interfering RNA (siRNA) can selectively suppress the expression of disease-causing genes, holding great promise in the treatment of human diseases, including malignant cancers. In recent years, with the development of chemical modification and delivery technology, several siRNA-based therapeut...