ICOS gene polymorphisms in B-cell chronic lymphocytic leukemia in the Polish population

• Published in: Folia histochemica et cytobiologica Vol. 49; no. 1; pp. 49 - 54
• Main Authors: Karabon, Lidia, Jedynak, Anna, Tomkiewicz, Anna, Wolowiec, Dariusz, Kielbinski, Marek, Woszczyk, Dariusz, Kuliczkowski, Kazimierz, Frydecka, Irena
• Format: Journal Article
• Language: English
• Published: Poland Wydawnictwo Via Medica 01.01.2011; Via Medica
• Subjects: Aged; Alleles; Antibodies; Antigens; Antigens, Differentiation, T-Lymphocyte - genetics; B-CLL; Case-Control Studies; CD28 antigen; Cell activation; Cell surface; Chronic lymphocytic leukemia; Cytokines; Disease Progression; Female; Follow-Up Studies; Gene polymorphism; Genotype; Genotyping; Haplotypes; Humans; ICOS; Immunology; Inducible T-Cell Co-Stimulator Protein; Interleukin 10; Interleukin 2; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell - genetics; Leukemia, Lymphocytic, Chronic, B-Cell - pathology; Lymphocytes; Lymphocytes B; Lymphocytes T; Lymphokines; Male; Middle Aged; Neoplasm Staging; Poland; Polymorphism, Genetic - genetics; polymorphisms; Population studies; Single-nucleotide polymorphism; Statistical analysis; Susceptibility; Tumors; Poland

There is strong evidence that altered immunological function entails an increased risk of B-cell chronic lymphocytic leukemia (B-CLL). The main mechanism of an anti-tumor response depends on T-cell activation. Unlike the constitutively expressed CD28, inducible costimulatory molecule (ICOS) is expre...