Inhibition of the oligosaccharides extracted from Morinda officinalis, a Chinese traditional herbal medicine, on the corticosterone induced apoptosis in PC12 cells
The mechanisms of the antidepressant action of the oligosaccharides (P 6) extracted from Morinda Officinalis were studied. By flow cytometry analysis, treatment of PC12 cells with corticosterone (Cort) induced apoptosis in a concentration and time dependent manner. The highest percentage of apoptoti...
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Published in | Life sciences (1973) Vol. 72; no. 8; pp. 933 - 942 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
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Elsevier Inc
10.01.2003
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Abstract | The mechanisms of the antidepressant action of the oligosaccharides (P
6) extracted from
Morinda Officinalis were studied. By flow cytometry analysis, treatment of PC12 cells with corticosterone (Cort) induced apoptosis in a concentration and time dependent manner. The highest percentage of apoptotic cells accumulated to 27.85 ± 9.2% following pretreatment with Cort 10 μM for 5 d. In agarose gel electrophoresis of DNA, the sample obtained from PC12 cells pretreated with Cort 10 μM for 5 d showed a typical ladder pattern suggesting that Cort increased the DNA fragmentation significantly. Furthermore, the ultrastructure of Cort-treated cells displayed typical apoptosis-like morphological changes including fragmented chromatin accumulation to the inside of nucleolus membrane with a shape like crescent moon or ring, nuclear fragmentation or apoptotic body. In the presence of P
6, or tricyclic antidepressant desipramine (DIM), the apoptosis induced by Cort in the three measurements above was significantly inhibited. These results indicate that DIM or P
6 antagonize the apoptosis induced by Cort in PC12 cells, which may be one of the cellular mechanisms of their antidepressant effects. |
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AbstractList | The mechanisms of the antidepressant action of the oligosaccharides (P(6)) extracted from Morinda Officinalis were studied. By flow cytometry analysis, treatment of PC12 cells with corticosterone (Cort) induced apoptosis in a concentration and time dependent manner. The highest percentage of apoptotic cells accumulated to 27.85 +/- 9.2% following pretreatment with Cort 10 microM for 5 d. In agarose gel electrophoresis of DNA, the sample obtained from PC12 cells pretreated with Cort 10 microM for 5 d showed a typical ladder pattern suggesting that Cort increased the DNA fragmentation significantly. Furthermore, the ultrastructure of Cort-treated cells displayed typical apoptosis-like morphological changes including fragmented chromatin accumulation to the inside of nucleolus membrane with a shape like crescent moon or ring, nuclear fragmentation or apoptotic body. In the presence of P(6), or tricyclic antidepressant desipramine (DIM), the apoptosis induced by Cort in the three measurements above was significantly inhibited. These results indicate that DIM or P(6) antagonize the apoptosis induced by Cort in PC12 cells, which may be one of the cellular mechanisms of their antidepressant effects. The mechanisms of the antidepressant action of the oligosaccharides (P 6) extracted from Morinda Officinalis were studied. By flow cytometry analysis, treatment of PC12 cells with corticosterone (Cort) induced apoptosis in a concentration and time dependent manner. The highest percentage of apoptotic cells accumulated to 27.85 ± 9.2% following pretreatment with Cort 10 μM for 5 d. In agarose gel electrophoresis of DNA, the sample obtained from PC12 cells pretreated with Cort 10 μM for 5 d showed a typical ladder pattern suggesting that Cort increased the DNA fragmentation significantly. Furthermore, the ultrastructure of Cort-treated cells displayed typical apoptosis-like morphological changes including fragmented chromatin accumulation to the inside of nucleolus membrane with a shape like crescent moon or ring, nuclear fragmentation or apoptotic body. In the presence of P 6, or tricyclic antidepressant desipramine (DIM), the apoptosis induced by Cort in the three measurements above was significantly inhibited. These results indicate that DIM or P 6 antagonize the apoptosis induced by Cort in PC12 cells, which may be one of the cellular mechanisms of their antidepressant effects. |
Author | Gong, Zheng Hua Yang, Ming Zhao, Yi Min Li, Yun Feng Luo, Zhi Pu |
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Keywords | Oligosaccharides Desipramine Corticosterone Morinda officinalis Cells Apoptosis |
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Snippet | The mechanisms of the antidepressant action of the oligosaccharides (P
6) extracted from
Morinda Officinalis were studied. By flow cytometry analysis,... The mechanisms of the antidepressant action of the oligosaccharides (P(6)) extracted from Morinda Officinalis were studied. By flow cytometry analysis,... |
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SubjectTerms | Animals Antidepressive Agents - pharmacology Apoptosis Cell Count Cells Corticosterone Corticosterone - pharmacology Desipramine Desipramine - pharmacology DNA Fragmentation - drug effects Dose-Response Relationship, Drug Drug Antagonism Drugs, Chinese Herbal - isolation & purification Drugs, Chinese Herbal - pharmacology Flow Cytometry Morinda - chemistry Morinda officinalis Oligosaccharides Oligosaccharides - isolation & purification Oligosaccharides - pharmacology PC12 PC12 Cells - drug effects PC12 Cells - ultrastructure Rats |
Title | Inhibition of the oligosaccharides extracted from Morinda officinalis, a Chinese traditional herbal medicine, on the corticosterone induced apoptosis in PC12 cells |
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