Effects of combined inhibition of ATP-sensitive potassium channels, nitric oxide, and prostaglandins on hyperemia during moderate exercise

• Published in: Journal of applied physiology (1985) Vol. 100; no. 5; pp. 1506 - 1512
• Main Authors: Schrage, William G, Dietz, Niki M, Joyner, Michael J
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Am Physiological Soc 01.05.2006; American Physiological Society
• Subjects: Adenosine; Adenosine Triphosphate - physiology; Adult; ATP; Biological and medical sciences; Enzyme Inhibitors - pharmacology; Exercise; Exercise - physiology; Female; Forearm - blood supply; Forearm - physiology; Fundamental and applied biological sciences. Psychology; Glyburide - pharmacology; Human subjects; Humans; Hyperemia - physiopathology; Inhibitor drugs; Ketorolac - pharmacology; Male; Muscle, Skeletal - blood supply; Muscle, Skeletal - physiopathology; NG-Nitroarginine Methyl Ester - pharmacology; Nitric oxide; Nitric Oxide - antagonists & inhibitors; Nitric Oxide - physiology; Potassium; Potassium Channels - drug effects; Potassium Channels - physiology; Prostaglandins - physiology; Regional Blood Flow - drug effects; Regional Blood Flow - physiology; Ultrasonic imaging; Vasodilation - drug effects; Vasodilation - physiology; Young adults; Physical exercise; Prostaglandin-endoperoxide synthase; NG-nitro-L-arginine methyl ester; Ionic channel; Inorganic element; Doppler ultrasound; Arginine; Eicosanoid; Inhibition; nitric oxide synthase; Ultrasound; Human; Prostaglandin; Enzyme; Arachidonic acid derivatives; cyclooxygenase; Nitric-oxide synthase; Blood flow; Vertebrata; Mammalia; Aminoacid; Nitric oxide; Hemodynamics; Oxidoreductases; ATP; Potassium
• ISSN: 8750-7587; 1522-1601
• DOI: 10.1152/japplphysiol.01639.2005

1 Department of Anesthesiology and 2 General Clinical Research Center, Mayo Clinic, Rochester, Minnesota Submitted 30 December 2005 ; accepted in final form 6 February 2006 ATP-sensitive potassium (K ATP ) channels have been suggested to contribute to coronary and skeletal muscle vasodilation during...