MicroRNA-302a-3p induces ferroptosis of non-small cell lung cancer cells via targeting ferroportin

• Published in: Free radical research Vol. 55; no. 7; pp. 722 - 731
• Main Authors: Wei, Dong, Ke, Yao-Qi, Duan, Peng, Zhou, Lei, Wang, Chang-Ying, Cao, Ping
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 03.07.2021
• Subjects: Apoptosis; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Carcinoma, Non-Small-Cell Lung - genetics; Carcinoma, Non-Small-Cell Lung - metabolism; Carcinoma, Non-Small-Cell Lung - pathology; Cation Transport Proteins - antagonists & inhibitors; Cation Transport Proteins - genetics; Cation Transport Proteins - metabolism; Cell Proliferation; ferroportin; Ferroptosis; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms - genetics; Lung Neoplasms - metabolism; Lung Neoplasms - pathology; MicroRNAs - genetics; miR-302a-3p; NSCLCs; Tumor Cells, Cultured; ferroportin; ferroptosis; miR-302a-3p; NSCLCs

Ferroptosis is a newly described regulated form of cell death that contributes to the progression of non-small cell lung cancers (NSCLCs). MicroRNA-302a-3p (miR-302a-3p) plays critical roles in the tumorigenicity of different cancers; however, its function and underlying mechanism in ferroptosis and...