Comparison of in vivo derived and scaled in vitro metabolic rate constants for several volatile organic compounds (VOCs)

• Published in: Toxicology in vitro Vol. 69; p. 105002
• Main Authors: Kenyon, Elaina M., Eklund, Christopher, Pegram, Rex A., Lipscomb, John C.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.12.2020; Elsevier Science Ltd
• Subjects: Allyl Compounds - pharmacokinetics; Animals; Binding; Biotransformation; Bromodichloromethane; Chemicals; Data collection; Hydrocarbons, Chlorinated - pharmacokinetics; in vitro to in vivo extrapolation; In vivo methods and tests; IVIVE; Laboratory animals; Male; Metabolic Clearance Rate; Metabolic rate; Metabolic rate parameters; Metabolism; Models, Biological; Organic compounds; Parameter estimation; PBPK; Physiologically based pharmacokinetic modeling; Propane - analogs & derivatives; Propane - pharmacokinetics; Rate constants; Rats, Inbred F344; VOCs; Volatile organic compounds; Volatile Organic Compounds - pharmacokinetics; Volatile organic compounds; Physiologically based pharmacokinetic modeling; Biotransformation; IVIVE; Metabolic rate parameters; in vitro to in vivo extrapolation; PBPK

Metabolic rate parameters estimation using in vitro data is necessary due to numbers of chemicals for which data are needed, trend towards minimizing laboratory animal use, and limited opportunity to collect data in human subjects. We evaluated how well metabolic rate parameters derived from in vitr...