Comparison of in vivo derived and scaled in vitro metabolic rate constants for several volatile organic compounds (VOCs) - Kenyon, Elaina M.; Eklund, Christopher; Pegram, Rex A.; Lipscomb, John C. (Toxicology in vitro, 2020)
Keywords: Allyl Compounds - pharmacokinetics; Animals; Binding; Biotransformation; Bromodichloromethane; Chemicals; Data collection; Hydrocarbons, Chlorinated - pharmacokinetics; in vitro to in vivo extrapolation; In vivo methods and tests; IVIVE; Laboratory animals; Male; Metabolic Clearance Rate; Metabolic rate; Metabolic rate parameters; Metabolism; Models, Biological; Organic compounds; Parameter estimation; PBPK; Physiologically based pharmacokinetic modeling; Propane - analogs & derivatives; Propane - pharmacokinetics; Rate constants; Rats, Inbred F344; VOCs; Volatile organic compounds; Volatile Organic Compounds - pharmacokinetics; Volatile organic compounds; Physiologically based pharmacokinetic modeling; Biotransformation; IVIVE; Metabolic rate parameters; in vitro to in vivo extrapolation; PBPK