Puerarin attenuates pressure overload-induced cardiac hypertrophy

• Published in: Journal of cardiology Vol. 63; no. 1; pp. 73 - 81
• Main Authors: Yuan, Yuan, PhD, Zong, Jing, PhD, Zhou, Heng, PhD, Bian, Zhou-Yan, PhD, Deng, Wei, PhD, Dai, Jia, PhD, Gan, Hua-Wen, MD, Yang, Zheng, PhD, Li, Hongliang, PhD, Tang, Qi-Zhu, PhD
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.01.2014
• Subjects: Administration, Oral; Animals; Aortic coarctation; Apoptosis - drug effects; Apoptosis - genetics; bcl-2-Associated X Protein; Cardiomegaly - drug therapy; Cardiomegaly - etiology; Cardiomegaly - genetics; Cardiomegaly - prevention & control; Cardiotonic Agents - administration & dosage; Cardiotonic Agents - pharmacology; Cardiovascular; Cells, Cultured; Disease Progression; Fibrosis; Gene Expression - drug effects; Heart Failure - drug therapy; Heart Failure - etiology; Heart Failure - prevention & control; Hypertrophy; Isoflavones - administration & dosage; Isoflavones - pharmacology; Male; MAP Kinase Signaling System - drug effects; Mice; Mice, Inbred C57BL; Myocardium - pathology; Myocytes, Cardiac - pathology; Pharmacology; Phosphatidylinositol 3-Kinases - antagonists & inhibitors; Phytotherapy; Pressure - adverse effects; Vasodilator Agents - administration & dosage; Vasodilator Agents - pharmacology; Aortic coarctation; Pharmacology; Hypertrophy

Abstract Background Puerarin is the most abundant isoflavonoid in kudzu root. It has been used to treat angina pectoris and myocardial infarction clinically. However, little is known about the effect of puerarin on cardiac hypertrophy. Methods Aortic banding (AB) was performed to induce cardiac hype...