Novel TENM3–ALK fusion is an alternate mechanism for ALK activation in neuroblastoma

• Published in: Oncogene Vol. 41; no. 20; pp. 2789 - 2797
• Main Authors: Hiwatari, Mitsuteru, Seki, Masafumi, Matsuno, Ryosuke, Yoshida, Kenichi, Nagasawa, Takeshi, Sato-Otsubo, Aiko, Yamamoto, Shohei, Kato, Motohiro, Watanabe, Kentaro, Sekiguchi, Masahiro, Miyano, Satoru, Ogawa, Seishi, Takita, Junko
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 13.05.2022; Nature Publishing Group
• Subjects: 13/1; 13/106; 13/109; 13/44; 14/32; 38/109; 38/61; 38/77; 38/91; 631/67/2332; 631/67/395; 631/80/304; 64/60; 82/1; 82/80; AKT protein; Anaplastic Lymphoma Kinase - genetics; Animals; Apoptosis; Cell Biology; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic - genetics; Chromosome 19; Extracellular signal-regulated kinase; Fusion protein; Human Genetics; Humans; Internal Medicine; Kinases; Medicine; Medicine & Public Health; Membrane Proteins - genetics; Mice; Mice, Inbred NOD; Nerve Tissue Proteins - genetics; Neuroblastoma; Neuroblastoma - pathology; NIH 3T3 Cells; Oncogene Proteins, Fusion - genetics; Oncology; Patients; Protein-tyrosine kinase; Proteins; Receptor Protein-Tyrosine Kinases - metabolism; Stat3 protein; Therapeutic targets; Translocation, Genetic - genetics; Tumor cells; Tumorigenesis

The identification of molecular events underlying the pathogenesis of neuroblastoma can likely result in improved clinical outcomes for this disease. In this study, a translocation within chromosome 2p and 4q was found to bring about the formation of an in-frame fusion gene that was composed of port...