A novel description of FDG excretion in the renal system: application to metformin-treated models

• Published in: Magma (New York, N.Y.) Vol. 59; no. 10; pp. 2469 - 2484
• Main Authors: Garbarino, S, Caviglia, G, Sambuceti, G, Benvenuto, F, Piana, M
• Format: Journal Article
• Language: English
• Published: England IOP Publishing 21.05.2014; Springer Verlag
• Subjects: Algorithms; Animals; compartmental models; Computer Science; FDG excretion; Fluorodeoxyglucose F18 - metabolism; Glucose - metabolism; Image Processing; Kidney - diagnostic imaging; Kidney - drug effects; Kidney - metabolism; Likelihood Functions; metformin; Metformin - pharmacology; Mice; Models, Biological; parameter identification; Phosphorylation - drug effects; Positron-Emission Tomography; Radioactive Tracers; Signal and Image Processing

This paper introduces a novel compartmental model describing the excretion of 18F-fluoro-deoxyglucose (FDG) in the renal system and a numerical method based on the maximum likelihood for its reduction. This approach accounts for variations in FDG concentration due to water re-absorption in renal tub...