Polymorphisms in DNA Repair Genes and Association with Rheumatoid Arthritis in a Pilot Study on a Central European Population

• Published in: International journal of molecular sciences Vol. 24; no. 4; p. 3804
• Main Authors: Galita, Grzegorz, Sarnik, Joanna, Brzezinska, Olga, Budlewski, Tomasz, Dragan, Grzegorz, Poplawska, Marta, Majsterek, Ireneusz, Poplawski, Tomasz, Makowska, Joanna S.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 14.02.2023; MDPI
• Subjects: Arthritis; Arthritis, Rheumatoid - genetics; B cells; Case-Control Studies; Chronic illnesses; Development and progression; Disease; DNA; DNA damage; DNA methylation; DNA repair; DNA Repair - genetics; Genes; Genetic aspects; Genetic polymorphisms; Genetic Predisposition to Disease; Genetic research; Genotype; Humans; Hypotheses; Inflammation; Kinases; Lymphoma; Metabolism; Pathogenesis; Pilot Projects; Polymorphism, Genetic; Proteins; Remission (Medicine); Rheumatoid arthritis; Rheumatoid factor; Signal transduction; X-ray Repair Cross Complementing Protein 1 - genetics; Poland; DNA repair genes; SNP; DNA damage response; polymorphisms; rheumatoid arthritis

Rheumatoid arthritis (RA) is a chronic, multifactorial autoimmune disease characterized by chronic arthritis, a tendency to develop joint deformities, and involvement of extra-articular tissues. The risk of malignant neoplasms among patients with RA is the subject of ongoing research due to the auto...