Defects in memory B-cell and plasma cell subsets expressing different immunoglobulin-subclasses in patients with CVID and immunoglobulin subclass deficiencies

• Published in: Journal of allergy and clinical immunology Vol. 144; no. 3; pp. 809 - 824
• Main Authors: Blanco, Elena, Pérez-Andrés, Martín, Arriba-Méndez, Sonia, Serrano, Cristina, Criado, Ignacio, Del Pino-Molina, Lucía, Silva, Susana, Madruga, Ignacio, Bakardjieva, Marina, Martins, Catarina, Serra-Caetano, Ana, Romero, Alfonso, Contreras-Sanfeliciano, Teresa, Bonroy, Carolien, Sala, Francisco, Martín, Alejandro, Bastida, José María, Lorente, Félix, Prieto, Carlos, Dávila, Ignacio, Marcos, Miguel, Kalina, Tomas, Vlkova, Marcela, Chovancova, Zita, Cordeiro, Ana Isabel, Philippé, Jan, Haerynck, Filomeen, López-Granados, Eduardo, Sousa, Ana E., van der Burg, Mirjam, van Dongen, Jacques J.M., Orfao, Alberto
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2019; Elsevier Limited
• Subjects: Age; Antigens; Autoimmunity; CD27 antigen; classification; Common variable immunodeficiency; Defects; diagnosis; Flow cytometry; Immunodeficiency; Immunoglobulin A; Immunoglobulin G; immunoglobulin subclasses; Immunoglobulins; Immunological memory; immunophenotyping; Lymphocytes B; Medical diagnosis; memory B cells; Memory cells; plasma cells; primary antibody deficiency; Primary immunodeficiencies; selective IgA deficiency; primary antibody deficiency; IgH; LLN; MBC; CVID; immunophenotyping; NPV; PPV; selective IgA deficiency; flow cytometry; sm; GC; IgG/Adef; Immunodeficiency; immunoglobulin subclasses; diagnosis; ESID; common variable immunodeficiency; immunoglobulins; memory B cells; plasma cells; classification; PAD; PC; IUIS; HD; IgAdef

Predominantly antibody deficiencies (PADs) are the most prevalent primary immunodeficiencies, but their B-cell defects and underlying genetic alterations remain largely unknown. We investigated patients with PADs for the distribution of 41 blood B-cell and plasma cell (PC) subsets, including subsets...