Antioxidant Treatment Reduces Expansion and Contraction of Antigen-Specific CD8+ T Cells during Primary but Not Secondary Viral Infection

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Published inJournal of Virology Vol. 78; no. 20; pp. 11246 - 11257
Main Authors LANIEWSKI, Nathan G, GRAYSON, Jason M
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.10.2004
Subjects
Animals
Biological and medical sciences
CD8-Positive T-Lymphocytes - immunology
Female
Free Radical Scavengers - administration & dosage
Fundamental and applied biological sciences. Psychology
Immunologic Memory
Lymphocyte Activation - drug effects
Lymphocytic Choriomeningitis - immunology
Lymphocytic Choriomeningitis - virology
Lymphocytic choriomeningitis virus - immunology
Metalloporphyrins - administration & dosage
Mice
Mice, Inbred C57BL
Microbiology
Miscellaneous
Pathogenesis and Immunity
Reactive Oxygen Species - metabolism
Time Factors
Virology
Infection
Treatment
Microbiology
Primary infection
Viral disease
T-Lymphocyte
Antioxidant
T antigen
Virology
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Abstract Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue JVI About JVI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JVI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0022-538X Online ISSN: 1098-5514 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to JVI .asm.org, visit: JVI       
AbstractList ABSTRACT During many viral infections, antigen-specific CD8 + T cells undergo large-scale expansion. After viral clearance, the vast majority of effector CD8 + T cells undergo apoptosis. Previous studies have implicated reactive oxygen intermediates (ROI) in lymphocyte apoptosis. The purpose of the experiments presented here was to determine the role of ROI in the expansion and contraction of CD8 + T cells in vivo during a physiological response such as viral infection. Mice were infected with lymphocytic choriomeningitis virus (LCMV) and treated with Mn(III)tetrakis(4-benzoic acid)porphyrin chloride (MnTBAP), a metalloporphyrin-mimetic compound with superoxide dismutase activity, from days 0 to 8 postinfection. At the peak of CD8 + -T-cell response, on day 8 postinfection, the numbers of antigen-specific cells were 10-fold lower in MnTBAP-treated mice than in control mice. From days 8 to 30, a contraction phase ensued where the numbers of antigen-specific CD8 + T cells declined 25-fold in vehicle-treated mice compared to a 3.5-fold decrease in MnTBAP-treated mice. Differences in contraction appeared to be due to greater proliferation in drug-treated mice. By day 38, the numbers of antigen-specific CD8 + memory T cells were equivalent for the two groups. The administration of MnTBAP during secondary viral infection had no effect on the expansion of antigen-specific CD8 + secondary effector T cells. These data suggest that ROI production is critical for the massive expansion and contraction of antigen-specific CD8 + T cells during primary, but not secondary, viral infection.
During many viral infections, antigen-specific CD8 + T cells undergo large-scale expansion. After viral clearance, the vast majority of effector CD8 + T cells undergo apoptosis. Previous studies have implicated reactive oxygen intermediates (ROI) in lymphocyte apoptosis. The purpose of the experiments presented here was to determine the role of ROI in the expansion and contraction of CD8 + T cells in vivo during a physiological response such as viral infection. Mice were infected with lymphocytic choriomeningitis virus (LCMV) and treated with Mn(III)tetrakis(4-benzoic acid)porphyrin chloride (MnTBAP), a metalloporphyrin-mimetic compound with superoxide dismutase activity, from days 0 to 8 postinfection. At the peak of CD8 + -T-cell response, on day 8 postinfection, the numbers of antigen-specific cells were 10-fold lower in MnTBAP-treated mice than in control mice. From days 8 to 30, a contraction phase ensued where the numbers of antigen-specific CD8 + T cells declined 25-fold in vehicle-treated mice compared to a 3.5-fold decrease in MnTBAP-treated mice. Differences in contraction appeared to be due to greater proliferation in drug-treated mice. By day 38, the numbers of antigen-specific CD8 + memory T cells were equivalent for the two groups. The administration of MnTBAP during secondary viral infection had no effect on the expansion of antigen-specific CD8 + secondary effector T cells. These data suggest that ROI production is critical for the massive expansion and contraction of antigen-specific CD8 + T cells during primary, but not secondary, viral infection.
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During many viral infections, antigen-specific CD8(+) T cells undergo large-scale expansion. After viral clearance, the vast majority of effector CD8(+) T cells undergo apoptosis. Previous studies have implicated reactive oxygen intermediates (ROI) in lymphocyte apoptosis. The purpose of the experiments presented here was to determine the role of ROI in the expansion and contraction of CD8(+) T cells in vivo during a physiological response such as viral infection. Mice were infected with lymphocytic choriomeningitis virus (LCMV) and treated with Mn(III)tetrakis(4-benzoic acid)porphyrin chloride (MnTBAP), a metalloporphyrin-mimetic compound with superoxide dismutase activity, from days 0 to 8 postinfection. At the peak of CD8(+)-T-cell response, on day 8 postinfection, the numbers of antigen-specific cells were 10-fold lower in MnTBAP-treated mice than in control mice. From days 8 to 30, a contraction phase ensued where the numbers of antigen-specific CD8(+) T cells declined 25-fold in vehicle-treated mice compared to a 3.5-fold decrease in MnTBAP-treated mice. Differences in contraction appeared to be due to greater proliferation in drug-treated mice. By day 38, the numbers of antigen-specific CD8(+) memory T cells were equivalent for the two groups. The administration of MnTBAP during secondary viral infection had no effect on the expansion of antigen-specific CD8(+) secondary effector T cells. These data suggest that ROI production is critical for the massive expansion and contraction of antigen-specific CD8(+) T cells during primary, but not secondary, viral infection.
Author Jason M. Grayson
Nathan G. Laniewski
AuthorAffiliation Department of Microbiology and Immunology, Wake Forest University School of Medicine, Winston-Salem, North Carolina
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Corresponding author. Mailing address: 5100A Gray Building, Department of Microbiology and Immunology, Wake Forest University School of Medicine, Winston-Salem, NC 27157. Phone: (336) 716-0268. Fax: (336) 716-9928. E-mail: jgrayson@wfubmc.edu.
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Snippet Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley...
During many viral infections, antigen-specific CD8(+) T cells undergo large-scale expansion. After viral clearance, the vast majority of effector CD8(+) T...
ABSTRACT During many viral infections, antigen-specific CD8 + T cells undergo large-scale expansion. After viral clearance, the vast majority of effector CD8 +...
During many viral infections, antigen-specific CD8 + T cells undergo large-scale expansion. After viral clearance, the vast majority of effector CD8 + T cells...
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SubjectTerms Animals
Biological and medical sciences
CD8-Positive T-Lymphocytes - immunology
Female
Free Radical Scavengers - administration & dosage
Fundamental and applied biological sciences. Psychology
Immunologic Memory
Lymphocyte Activation - drug effects
Lymphocytic Choriomeningitis - immunology
Lymphocytic Choriomeningitis - virology
Lymphocytic choriomeningitis virus - immunology
Metalloporphyrins - administration & dosage
Mice
Mice, Inbred C57BL
Microbiology
Miscellaneous
Pathogenesis and Immunity
Reactive Oxygen Species - metabolism
Time Factors
Virology
Title Antioxidant Treatment Reduces Expansion and Contraction of Antigen-Specific CD8+ T Cells during Primary but Not Secondary Viral Infection
URI http://jvi.asm.org/content/78/20/11246.abstract
https://www.ncbi.nlm.nih.gov/pubmed/15452243
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