Plasma B Lymphocyte Stimulator and B Cell Differentiation in Idiopathic Pulmonary Fibrosis Patients

• Published in: The Journal of immunology (1950) Vol. 191; no. 5; pp. 2089 - 2095
• Main Authors: Xue, Jianmin, Kass, Daniel J, Bon, Jessica, Vuga, Louis, Tan, Jiangning, Csizmadia, Eva, Otterbein, Leo, Soejima, Makoto, Levesque, Marc C, Gibson, Kevin F, Kaminski, Naftali, Pilewski, Joseph M, Donahoe, Michael, Sciurba, Frank C, Duncan, Steven R
• Format: Journal Article
• Language: English
• Published: United States 01.09.2013
• Subjects: Aged; Aged, 80 and over; B-Cell Activating Factor - blood; B-Lymphocytes - cytology; B-Lymphocytes - immunology; Cell Differentiation - immunology; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Humans; Idiopathic Pulmonary Fibrosis - blood; Idiopathic Pulmonary Fibrosis - immunology; Idiopathic Pulmonary Fibrosis - pathology; Immunohistochemistry; Male; Middle Aged
• ISSN: 0022-1767; 1550-6606; 1550-6606
• DOI: 10.4049/jimmunol.1203476

We hypothesized B cells are involved in the pathogenesis of idiopathic pulmonary fibrosis (IPF), a progressive, restrictive lung disease that is refractory to glucocorticoids and other nonspecific therapies, and almost invariably lethal. Accordingly, we sought to identify clinically associated B cel...