Differential Analysis of Three Copper-Based Nanomaterials with Different Morphologies to Suppress Alternaria alternata and Safety Evaluation

• Published in: International journal of molecular sciences Vol. 24; no. 11; p. 9673
• Main Authors: Yuan, Zitong, Li, Yiwei, He, Yuke, Qian, Kun, Zhang, Yongqiang
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 02.06.2023; MDPI
• Subjects: Acute toxicity; Agrochemicals; Alternaria alternata; Antifungal activity; Antimicrobial agents; Copper; copper nanorods; copper nanowires; Copper oxides; cuprous oxide nanoparticles; Environmental impact; Food; Fungicides; Melanin; nano-pesticide; Nanomaterials; Nanoparticles; Nanotechnology; Nanowires; Oxidative stress; Pathogenesis; Pathogens; Pesticides; Plant diseases; Plant growth; Proteins; Toxicity; Virulence; Zebrafish; copper nanowires; Alternaria alternata; zebrafish; nano-pesticide; cuprous oxide nanoparticles; copper nanorods
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms24119673

The overuse of copper-based fertilizers and pesticides over the last few decades has resulted in detrimental risks to our environment. Nano-enabled agrichemicals with a high effective utilization ratio have shown great potential for maintaining or minimizing environmental issues in agriculture. Copper-based nanomaterials (Cu-based NMs) serve as a promising alternative to fungicides. Three types of Cu-based NMs with different morphologies were analyzed for their different antifungal effects on in this current study. Compared to commercial copper hydroxide water power (Cu(OH) WP), all tested Cu-based NMs, including cuprous oxide nanoparticles (Cu O NPs), copper nanorods (Cu NRs) and copper nanowires (Cu NWs), especially Cu O NPs and Cu NWs, showed higher antifungal activity against . Its EC were 104.24 and 89.40 mg L , respectively, achieving comparable activity using a dose approximately 1.6 and 1.9-fold lower. Cu-based NMs could introduce the downregulation of melanin production and soluble protein content. In contrast to trends in antifungal activity, Cu O NPs showed the strongest power in regulating melanin production and protein content and similarly exhibited the highest acute toxicity to adult zebrafish compared to other Cu-based NMs. These results demonstrate that Cu-based NMs could offer great potential in plant disease management strategies.