Counteracting neuronal nitric oxide synthase proteasomal degradation improves glucose transport in insulin-resistant skeletal muscle from Zucker fa/fa rats - Mezghenna, Karima; Leroy, Jérémy; Azay-Milhau, Jacqueline; Tousch, Didier; Castex, Françoise; Gervais, Sylvain; Delgado-Betancourt, Viviana; Gross, René; Lajoix, Anne-Dominique (Diabetologia, 2014)
Keywords: Animals; Biological and medical sciences; Blotting, Western; Cells, Cultured; Diabetes; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Enzymes; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Fundamental and applied biological sciences. Psychology; Glucose; Glucose - metabolism; Glucose Transporter Type 4 - metabolism; Human Physiology; Immunoprecipitation; Insulin resistance; Insulin Resistance - physiology; Internal Medicine; Life Sciences; Male; Medical sciences; Medicine; Medicine & Public Health; Metabolic Diseases; Muscle Cells - metabolism; Muscle, Skeletal - metabolism; Musculoskeletal system; Nitric oxide; Nitric Oxide Synthase Type I - genetics; Nitric Oxide Synthase Type I - metabolism; Obesity; Proteasome Endopeptidase Complex - metabolism; Proteins; Rats; Rats, Zucker; Reverse Transcriptase Polymerase Chain Reaction; Striated muscle. Tendons; Vertebrates: osteoarticular system, musculoskeletal system; United Kingdom--UK; France; Type 2 diabetes; NO synthase; Obesity; Insulin resistance; Skeletal muscle; Endocrinopathy; Pancreatic hormone; Rat; Enzyme; Biological transport; Rodentia; Nutrition disorder; Metabolic diseases; Glucose; Striated muscle; Insulin; Nitric-oxide synthase; Degradation; Target tissue resistance; Vertebrata; Mammalia; Animal; Oxidoreductases; Nutritional status