Meta-analysis of the effects of eicosapentaenoic acid (EPA) in clinical trials in depression

• Published in: The journal of clinical psychiatry Vol. 72; no. 12; p. 1577
• Main Authors: Sublette, M Elizabeth, Ellis, Steven P, Geant, Amy L, Mann, J John
• Format: Journal Article
• Language: English
• Published: United States 01.12.2011
• Subjects: Depressive Disorder, Major - drug therapy; Docosahexaenoic Acids - therapeutic use; Eicosapentaenoic Acid - therapeutic use; Humans; Placebos; Randomized Controlled Trials as Topic - methods; Randomized Controlled Trials as Topic - trends; Treatment Outcome

Randomized trials of omega-3 polyunsaturated fatty acid (PUFA) treatment for depression have differed in outcome. Recent meta-analyses ascribe discrepancies to differential effects of eicosapentaenoic acid (EPA) versus docosahexaenoic acid (DHA) and to diagnostic heterogeneity. This meta-analysis te...