Deep Brain Stimulation of the Subthalamic Nucleus Alters the Cortical Profile of Response Inhibition in the Beta Frequency Band: A Scalp EEG Study in Parkinson's Disease

• Published in: The Journal of neuroscience Vol. 31; no. 15; pp. 5721 - 5729
• Main Authors: Swann, Nicole, Poizner, Howard, Houser, Melissa, Gould, Sherrie, Greenhouse, Ian, Cai, Weidong, Strunk, Jon, George, Jobi, Aron, Adam R.
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 13.04.2011
• Subjects: Aged; Beta Rhythm - physiology; Cerebral Cortex - physiology; Deep Brain Stimulation - methods; Electrodes, Implanted; Electroencephalography; Female; Humans; Male; Middle Aged; Parkinson Disease - physiopathology; Parkinson Disease - psychology; Parkinson Disease - therapy; Reaction Time - physiology; Subthalamic Nucleus - physiology

Stopping an initiated response could be implemented by a fronto-basal-ganglia circuit, including the right inferior frontal cortex (rIFC) and the subthalamic nucleus (STN). Intracranial recording studies in humans reveal an increase in beta-band power (∼16–20 Hz) within the rIFC and STN when a respo...