Quercetin improves the imbalance of Th1/Th2 cells and Treg/Th17 cells to attenuate allergic rhinitis

• Published in: Autoimmunity (Chur, Switzerland) Vol. 56; no. 1; p. 2189133
• Main Authors: Ke, Xia, Chen, Ziqi, Wang, Xiaoqiang, Kang, Houyong, Hong, Suling
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 31.12.2023; Taylor & Francis Group
• Subjects: allergic rhinitis; Animals; Cytokines - metabolism; Disease Models, Animal; Immunoglobulin G - metabolism; Inflammation - metabolism; Mice; Mice, Inbred BALB C; Nasal Mucosa; NF-kappa B - metabolism; NF-κB pathway; Quercetin; Quercetin - pharmacology; Quercetin - therapeutic use; Rhinitis, Allergic - drug therapy; T-Lymphocytes, Regulatory - metabolism; Th1/Th2; Th17 Cells - metabolism; Th2 Cells - metabolism; Treg/Th17; Th1/Th2; Treg/Th17; allergic rhinitis; NF-κB pathway; Quercetin

Allergic rhinitis (AR) is a common inflammation that affects many people globally. Quercetin has anti-allergic biological activity in AR. Here, we aimed to explore the effects of quercetin on type 1 helper T (Th1)/Th2 and regulatory T cells (Treg)/Th17 balance. We established an ovalbumin (OVA)-indu...