Upregulation of Monocyte/Macrophage HGFIN (Gpnmb/Osteoactivin) Expression in End-Stage Renal Disease

• Published in: Clinical journal of the American Society of Nephrology Vol. 5; no. 1; pp. 56 - 61
• Main Authors: Pahl, Madeleine V., Vaziri, Nosratola D., Yuan, Jun, Adler, Sharon G.
• Format: Journal Article
• Language: English
• Published: United States American Society of Nephrology 01.01.2010
• Series: Original Articles
• Subjects: Cells, Cultured; Humans; Kidney Failure, Chronic - metabolism; Macrophages - metabolism; Membrane Glycoproteins; Membrane Proteins - biosynthesis; Middle Aged; Monocytes - metabolism; Original; Up-Regulation

Hematopoietic growth factor-inducible neurokinin 1 (HGFIN), also known as Gpnmb and osteoactivin, is a transmembrane glycoprotein that is expressed in numerous cells, including osteoclasts, macrophages, and dendritic cells. It serves as an osteoblast differentiation factor, participates in bone mine...