Novel population of human monocyte and osteoclast progenitors from pluripotent stem cells and peripheral blood

• Published in: Blood advances Vol. 5; no. 21; pp. 4435 - 4446
• Main Authors: Root, Sierra H., Aguila, Héctor L.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 09.11.2021; American Society of Hematology
• Subjects: Animals; Bone Marrow Cells; Cell Differentiation; Hematopoiesis and Stem Cells; Humans; Mice; Monocytes; Osteoclasts; Phagocytes, Granulocytes, and Myelopoiesis; Pluripotent Stem Cells

Osteoclasts are multinuclear cells of monocytic lineage, with the ability to resorb bone. Studies in mouse have identified bone marrow clonal progenitors able to generate mature osteoclast cells (OCs) in vitro and in vivo. These osteoclast progenitors (OCPs) can also generate macrophages and dendrit...